Objectifs du cours
Microfluidics has rapidly evolved to one of the commercially most successful fields in microsystem research. Developments are frequently coupled to novel applications in the life sciences, chemistry and medicine. One very important enabling technology in commerical drug development, diagnostics and biotechnology is the delivery of minute amounts of liquid to micro well plates and other substrates for assay miniaturization. Various miniaturized systems have been fabricated by means of microfabrication so far, providing superior performance over conventional technologies.
Engineering microfluidic systems involves detailed knowledge on the properties and dynamics of the fluids to be processed as well as their interaction with materials and structures. The devices and their components are fabricated by distinct micromachining techniques that fullfil the often very stringent requirements on costs, reliability and compatibility of materials and by this constitute a “microfluidic platform”. After introducing the concept of microfluidic platforms with some application examples, the course outlines the fundamentals of microfluidics with focus on assay miniaturization and non-contact liquid handling.
The physics of non-contact dispensing devices is explained in detail with reference to microarray fabrication. Finally a large section of the course is devoted to microarray technology, its applications and practical issues when fabricating microarrays.
Public cible
Microfluidic research is a multidisciplinary field involving microtechnology, analytical chemistry, biotechnology, pharmacology, physics, hydrodynamics, optics and other fields. The course is well-suited for experts active in these areas and also provides a broad overview for researchers and engineers that want to get involved in microfluidics, assay miniaturization or microarrays.
Contenu
- Overview on microfluidic platforms
- Fundamentals of microfluidics
- Assay miniaturization and well plate technology
- Pipetting of BioFluids & Physics of droplet formation
- Microarray fabrication technologies, substrates & array processing
- Detection methods and alternative microfluidic concepts.
Enseignant(s)
Dr. Peter Koltay is leading senior scientist at the Department for MEMS applications at the IMTEK of the University of Freiburg, Germany and Managing Director of BioFluidix GmbH.
His special interest in the microfluidic research and teaching is in the following areas:
- The development of new technical methods for micro dispensing and for the quality control of droplet dispensing systems
- The understanding and modelling of droplet formation, free-jet dispensing and all kinds of two-phase flow with free surfaces in a variety of applications
- The development of passive micro methanol fuel cells and the simulation of capillary transport processes in those systems
- The modeling and simulation of microfluidic systems with analytical and numerical methods
Dr. Günter Roth is Group Leader Lab-on-a-chip Assays at the Department of MEMS-Applications at the University of Freiburg, Germany.
His special interest in the microfluidic research and teaching is in the following:
- Development, implementation, improvement of assays in a centrifugal or pressure driven microfluidic device
- Detection and quantification of intermolecular interactions (binding, conformation change, activity change, phosphorylation)
- Quantification and characterization of surface coatings in means of molecular density, activity, compatibility to PCR or Immuno- or Clinical assays
- Development of new methods in life sciences (down to single cell analysis as well as up to screening of billions of different assays in one run)
2 days
CHF 1'200.00
EUR 1'000.00
Peter Koltay
Günter Roth
